Ethyl potassium malonate

• Catalog No.: A10720
• CAS Number: 6148-64-7
• M. F.: C5H7KO4
• M. W.: 170.20498
• Purity: 98%

SYNONYMS

• Title: 丙二酸单乙酯单钾盐
• IUPAC name: potassium 3-ethoxy-3-oxopropanoate
• IUPAC Traditional name: potassium monoethyl malonate
• Synonyms: Malonic acid monoethyl ester potassium salt; Monoethyl malonate potassium salt

DATABASE IDS

• CAS Number: 6148-64-7
• Beilstein Number: 3721682
• MDL Number: MFCD00035603
• EC Number: 228-156-7

PROPERTIES

• Purity: 98%
• Melting Point: ca 200°C dec.
• Storage Warning: Hygroscopic
• TSCA Listed: 否

REFERENCES

• An improved method for acylation with acid chlorides utilizes the Rathke MgCl₂-triethylamine reagent in acetonitrile or ethyl acetate to give ?-keto esters in very high yields: Synthesis, 290 (1993):
  
• Compare Diethyl malonate, A15468 and Dimethyl malonate, A11007, for other applications of this technique. See also Ethyl hydrogen malonate, A12627.
• Alternatively, ?-keto esters can be obtained in high yield by reaction with TMS chloride to generate ethyl trimethylsilyl malonate, followed by in situ reaction with acyl imidazoles or acyl chlorides in the presence of DBU: Tetrahedron Lett., 35, 9323 (1994).