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1-Bromo-2-fluorobenzene

Catalog No. A10635 Name Alfa Aesar
CAS Number 1072-85-1 Website
M. F. C6H4BrF Telephone
M. W. 174.9983632 Fax
Purity 99% Email
Storage Chembase ID: 6900

SYNONYMS

Title
1-溴-2-氟苯
IUPAC name
1-bromo-2-fluorobenzene
IUPAC Traditional name
1-bromo-2-fluorobenzene
Synonyms
2-Bromofluorobenzene

DATABASE IDS

MDL Number MFCD00000282
Beilstein Number 1071819
EC Number 214-018-3
CAS Number 1072-85-1

PROPERTIES

Purity 99%
Boiling Point 155-157°C
Density 1.601
Flash Point 43°C(109°F)
Melting Point -8°C
Refractive Index 1.5340
GHS Pictograms GHS02
GHS Pictograms GHS07
GHS Hazard statements H226-H302-H319
European Hazard Symbols X
GHS Precautionary statements P280F-P305+P351+P338
Risk Statements 10-22-36
RTECS DA1050000
Safety Statements 26-36
TSCA Listed
Hazard Class 3
UN Number UN1993
Packing Group III

DETAILS

REFERENCES

  • On treatment with Mg: J. Org. Chem., 49, 4518 (1984), or n-BuLi: Tetrahedron, 48, 4379 (1992), benzyne is generated, which undergoes [4+2] cycloadditions with furans or pyrroles.
  • Whereas n-BuLi effects bromine-metal exchange, lithiation with LDA at -75o results in deprotonation ortho to F; subsequent reaction with electrophiles provides access to mixed dihalo derivatives such as 3-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 36, 881 (1995). Improved yields are obtained by the use of lithium 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).