4-Methoxytrityl chloride

• Catalog No.: A10545
• CAS Number: 14470-28-1
• M. F.: C20H17ClO
• M. W.: 308.80138
• Purity: 97%

SYNONYMS

• Title: 4-甲氧基三苯甲基氯
• IUPAC name: 1-(chlorodiphenylmethyl)-4-methoxybenzene
• IUPAC Traditional name: 1-(chlorodiphenylmethyl)-4-methoxybenzene
• Synonyms: 4-Methoxytriphenylmethyl chloride; p-Anisylchlorodiphenylmethane

DATABASE IDS

• CAS Number: 14470-28-1
• Beilstein Number: 798425
• MDL Number: MFCD00000814
• EC Number: 238-463-8

PROPERTIES

• Purity: 97%
• Melting Point: 121-125°C
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• Safety Statements: 26-37
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否

REFERENCES

• Reagent for protection of alcohols, cf Chlorotriphenylmethane, A11799, as their monomethoxytrityl (Mmt) ethers, intermediate in acid-lability between trityl (Trt) and dimethoxytrityl (Dmt); see 4,4'-Dimethoxytrityl chloride, A11626. For use of DMAP as a catalyst for methoxytritylation of alcohols and amines, see: Tetrahedron Lett., 21, 3899 (1980); J. Org. Chem., 47, 571 (1982); Chem. Lett., 15 (1982).
• In a comparison with Dmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).