Morpholine

• Catalog No.: A10355
• CAS Number: 110-91-8
• M. F.: C4H9NO
• M. W.: 87.12036
• Purity: 99%

SYNONYMS

• Title: 吗啉
• IUPAC name: morpholine
• IUPAC Traditional name: morpholine

DATABASE IDS

• EC Number: 203-815-1
• Merck Index: 146277
• CAS Number: 110-91-8
• Beilstein Number: 102549
• MDL Number: MFCD00005972

PROPERTIES

• Purity: 99%
• Boiling Point: 129°C
• Density: 1.007
• Flash Point: 35°C(95°F)
• Melting Point: -5°C
• Refractive Index: 1.4540
• GHS Hazard statements: H314-H226-H302-H312-H332
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 10-20/21/22-34
• RTECS: QD6475000
• Safety Statements: 23-36-45
• Storage Warning: Hygroscopic
• TSCA Listed: 是
• Hazard Class: 8
• UN Number: UN2054
• Packing Group: I

REFERENCES

• Reagent for the cleavage of Fmoc protecting groups in peptide synthesis (see 9-Fluorenylmethyl chloroformate, A11683): J. Am. Chem. Soc., 92, 5748 (1970); J. Org. Chem., 37, 3404 (1972). See Appendix 6 for peptide reagents.
• In the Kindler modification of the Willgerodt reaction, aryl ketones are converted to ω-arylalkanoic acids by reaction with sulfur and an amine, usually morpholine: Org. Synth. Coll., 9, 99 (1998); reviews: Org. React., 3, 83 (1946); Synthesis, 358 (1975).
• Lithium morpholide adds to aromatic aldehydes at low temperature, a useful means for the protection of the aldehyde group in lithiations: Tetrahedron Lett., 25, 4213 (1981); J. Org. Chem., 48, 2356 (1983).
• Chlorination with hypochlorite gives N-chloromorpholine, a useful reagent in strongly acid media for the selective chlorination of activated aromatics: Org. Synth. Coll., 8, 167 (1993), and references therein.