N-Hydroxysuccinimide

• Catalog No.: A10312
• CAS Number: 6066-82-6
• M. F.: C4H5NO3
• M. W.: 115.0874
• Purity: 98+%

SYNONYMS

• Title: N-羟基丁二酰亚胺
• IUPAC name: 1-hydroxypyrrolidine-2,5-dione
• IUPAC Traditional name: N-hydroxysuccinimide
• Synonyms: 1-Hydroxy-2,5-pyrrolidinedione; HOSu

DATABASE IDS

• CAS Number: 6066-82-6
• EC Number: 228-001-3
• Beilstein Number: 113913
• MDL Number: MFCD00005516

PROPERTIES

• Purity: 98+%
• Melting Point: 94-99°C
• Storage Warning: Hygroscopic
• TSCA Listed: 是

REFERENCES

• Reagent for the preparation of active N-hydroxysuccinimide esters for peptide coupling with minimum racemization: J. Am. Chem. Soc., 86, 1839 (1964), or as an additive in the DCC method (see N,N'-Dicyclohexylcarbodiimide, A10973) to suppress racemization: J. Am. Chem. Soc., 89, 7151 (1967). For peptide reagents, see Appendix 6.
• For a study of the aminolysis of N-hydroxysuccinimide esters, see: J. Org. Chem., 53, 3583 (1988).