2-(Chloromethyl)pyridine hydrochloride

• Catalog No.: A10226
• CAS Number: 6959-47-3
• M. F.: C6H7Cl2N
• M. W.: 164.03248
• Purity: 98%

SYNONYMS

• Title: 2-(氯甲基)吡啶盐酸盐
• IUPAC name: 2-(chloromethyl)pyridine hydrochloride
• IUPAC Traditional name: 2-(chloromethyl)pyridine hydrochloride
• Synonyms: 2-Picolyl chloride hydrochloride

DATABASE IDS

• EC Number: 230-149-9
• CAS Number: 6959-47-3
• MDL Number: MFCD00012811
• Beilstein Number: 3689155

PROPERTIES

• Purity: 98%
• Melting Point: 120-124°C
• GHS Hazard statements: H301-H311-H317-H314-H318
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
• Risk Statements: 21/22-34-43
• RTECS: US6825000
• Safety Statements: 24-26-36/37/39-45
• Storage Warning: Hygroscopic
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN3261
• Packing Group: III

REFERENCES

• The free base has also been used for the protection of OH groups as 2-picolyl derivatives, relatively stable to acid (HF, TFA) but selectively cleaved by electrolytic reduction: Acta Chem. Scand. B, B37, 475 (1983); J. Chem. Res. (Synop.), 22 (1977).
• For a study of the base-catalyzed alkylation of p-t-butylcalix[5]arene, see: J. Org. Chem., 61, 2407 (1996).
• The free base, generated from the hydrochloride with aqueous OH^-, can be metallated (LDA, -78^o) at the methylene group. Subsequent reaction with a ketone provides a route to otherwise inaccessible pyridyloxiranes: Tetrahedron Lett., 35, 3175 (1994). Similarly, reaction of the lithio derivative with an imine gives a pyridylaziridine, generally in good yield: J. Org. Chem., 60, 2279 (1995).