Phthalan

• Catalog No.: A10217
• CAS Number: 496-14-0
• M. F.: C8H8O
• M. W.: 120.14852
• Purity: 98%

SYNONYMS

• Title: 1,3-二氢异苯并呋喃
• IUPAC name: 1,3-dihydro-2-benzofuran
• IUPAC Traditional name: phthalan
• Synonyms: 1,3-Dihydrobenzo[c]furan; 1,3-Dihydroisobenzofuran

DATABASE IDS

• EC Number: 207-815-2
• MDL Number: MFCD00005932
• Beilstein Number: 111932
• CAS Number: 496-14-0

PROPERTIES

• Purity: 98%
• Boiling Point: 192°C
• Density: 1.094
• Flash Point: 63°C(145°F)
• Refractive Index: 1.5460
• GHS Hazard statements: H227
• GHS Precautionary statements: P210-P280-P370+P378A-P403+P235-P501A
• TSCA Listed: 否

REFERENCES

• Treatment of phthalan with excess Li metal in the presence of 4,4'-Di-tert-butylbiphenyl, B21470, results in opening of the furan ring. Sequential introduction of two different electrophiles can be effected in the resulting bis-benzylic species, consequently phthalan can be regarded as an o-xylene dianion synthon. This approach provides a convenient access to diols and hydroxy acids which can be readily dehydrated to benzo-fused 6- or 7-membered cyclic ethers or lactones: Tetrahedron, 51, 3351 (1995); see also: J. Org. Chem., 61, 4913 (1996); Tetrahedron Lett., 39, 7759 (1998).
• For use in synthesis of nine-membered cyclic dione ethers, see: Synlett, 909 (1993).