1-Adamantanol

• Catalog No.: A10209
• CAS Number: 768-95-6
• M. F.: C10H16O
• M. W.: 152.23344
• Purity: 99%

SYNONYMS

• Title: 1-金刚醇
• IUPAC name: adamantan-1-ol
• IUPAC Traditional name: 1-hydroxyadamantane
• Synonyms: 1-Hydroxyadamantane

DATABASE IDS

• Beilstein Number: 1903952
• MDL Number: MFCD00074729
• CAS Number: 768-95-6
• EC Number: 212-202-8

PROPERTIES

• Purity: 99%
• Melting Point: ca 245°C subl.
• RTECS: AU4980000
• TSCA Listed: 否

REFERENCES

• Carboxyl groups of amino acids have been protected as 1-adamantyl esters via the amino acid tosylate and dimethyl sulfite. The group is readily cleaved with TFA under mild conditions: Synthesis, 1355 (1996). Has also been applied in blocking the ?-carboxyl group of aspartic acid in peptide synthesis; the 1-adamantyl ester is prepared using DCC-DMAP: J. Chem. Soc., Perkin 1, 2129 (1988). See also Appendix 6.
• Thiol groups may also be protected by formation of the thioether in TFA. Cleavage is by means of Hg(II) salts: Chem. Pharm. Bull., 26, 1576 (1978).
• Reaction with Hydrogen fluoride pyridine complex, L17117, gives 1-fluoroadamantane, a general method for conversion of sec- and tert-alcohols to fluoroalkanes: Org. Synth. Coll., 6, 628 (1988).