1-Dioxobenzo[b]thiophen-2-ylmethyl chloroformate

• Catalog No.: L19559
• CAS Number: 135204-19-2
• M. F.: C10H7ClO4S
• M. W.: 258.67818
• Purity: tech. 90%

SYNONYMS

• Title: 1,1-二氧-苯并噻吩-2-甲基 氯甲酸酯
• IUPAC name: (1,1-dioxo-1λ^6-benzothiophen-2-yl)methyl chloroformate
• IUPAC Traditional name: (1,1-dioxo-1λ^6-benzothiophen-2-yl)methyl chloroformate
• Synonyms: Benzo[b]thiophenesulfone-2-methoxycarbonyl chloride; Bsmoc-Cl

DATABASE IDS

• CAS Number: 135204-19-2
• MDL Number: MFCD01090984
• Beilstein Number: 8258946
• EC Number: 000-000-0

PROPERTIES

• Purity: tech. 90%
• Melting Point: 76-77°C
• GHS Hazard statements: H314-H318
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN3261
• Packing Group: II

REFERENCES

• Reagent introduced by Carpino for protection of amino acids as their benzothiophenesulfone-2-methoxycarbonyl (Bsmoc) derivatives, which represent a significant improvement in solid-phase peptide synthesis over the corresponding Fmoc derivatives. They are more readily cleaved by base, particularly tris(2-aminoethyl)amine: J. Am. Chem. Soc., 119, 9915 (1997); J. Org. Chem., 64, 4324 (1999).