1,3-Dichloroacetone

• Catalog No.: A14149
• CAS Number: 534-07-6
• M. F.: C3H4Cl2O
• M. W.: 126.96926
• Purity: 96%

SYNONYMS

• Title: 1,3-二氯丙酮
• IUPAC name: 1,3-dichloropropan-2-one
• IUPAC Traditional name: 1,3-dichloroacetone
• Synonyms: 1,3-Dichloro-2-propanone

DATABASE IDS

• Beilstein Number: 605456
• CAS Number: 534-07-6
• EC Number: 208-585-6
• MDL Number: MFCD00000937
• Merck Index: 143052

PROPERTIES

• Purity: 96%
• Boiling Point: 172-173°C
• Density: 1.383
• Flash Point: 95°C(203°F)
• Melting Point: 40-44°C
• Refractive Index: 1.4400
• GHS Hazard statements: H300-H310-H330-H314-H318-H341-H400-H410
• European Hazard Symbols: Highly toxic (T+)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P280-P305+P351+P338-P302+P352-P309-P310-P501A
• Risk Statements: 24-26/28-34-68-50/53
• RTECS: UC1430000
• Safety Statements: 26-28-36/37/39-45-60-61
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN2649
• Packing Group: II

REFERENCES

• Successive reaction with a Grignard reagent and Li metal leads to 1-substituted cyclopropanols, which rearrange on thermolysis to ethyl ketones: Synthesis, 647 (1983):
  
• The cyclization can also be induced by ethyl radicals, generated from ethylmagnesium bromide and FeCl₃. This method is applicable only to 1-arylcyclopropanols: J. Org. Chem., 29, 2813 (1964); 43, 3602 (1978); Org. Synth. Coll., 5, 1058 (1973).
• Formation of the acetal followed by treatment with NaNH₂ provides a route to cyclopropenones: Tetrahedron, 48, 2045 (1992).