Methanesulfonyl chloride

• Catalog No.: A13383
• CAS Number: 124-63-0
• M. F.: CH3ClO2S
• M. W.: 114.55132
• Purity: 98%

SYNONYMS

• Title: 甲磺酰氯
• IUPAC name: methanesulfonyl chloride
• IUPAC Traditional name: methanesulfonyl chloride
• Synonyms: Mesyl chloride

DATABASE IDS

• EC Number: 204-706-1
• MDL Number: MFCD00007454
• Beilstein Number: 506297
• Merck Index: 145955
• CAS Number: 124-63-0

PROPERTIES

• Purity: 98%
• Boiling Point: 161°C
• Density: 1.477
• Flash Point: 97°C(206°F)
• Melting Point: -33°C
• Refractive Index: 1.4520
• GHS Hazard statements: H300-H310-H330-H314-H318
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
• Risk Statements: 24/25-26-34
• RTECS: PB2790000
• Packing Group: I
• Safety Statements: 4-9-20-23-26-27-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN3246

REFERENCES

• Esters of hindered acids have been prepared via the mesyl mixed anhydride and reaction with the alcohol in the presence of DMAP: Synth. Commun., 12, 727 (1982).
• Reagent for conversion of alcohols to their mesylate esters. For mesylation of an acetylenic alcohol followed by displacement with an amine, see Org. Synth. Coll., 9, 46 (1998). In the presence of triethylamine, reaction occurs by way of the sulfene intermediate, which mesylates alcohols of low nucleophilicity including tert-alcohols and 2,2,2-trifluoroethanol: J. Org. Chem., 35, 3195 (1970).
• In pyridine, primary alcohols are converted to alkyl chlorides, via nucleophilic displacement by Cl^- on the mesylate: Chem. Pharm. Bull., 24, 365 (1976); J. Org. Chem., 48, 657 (1983). In combination with LiCl in collidine, allylic alcohols are converted to chlorides without allylic rearrangement: J. Org. Chem., 36, 3044 (1971).
• For use in the symmetrical coupling of aryl mesylates to give biaryls, catalyzed by Dichlorobis(triphenylphosphine)nickel(II), 13930, see: J. Org. Chem., 60, 6895 (1995).