Natamycin

• Catalog No.: DB00826
• CAS Number: 7681-93-8
• M. F.: C33H47NO13
• M. W.: 665.72518

SYNONYMS

• IUPAC name: (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^{5,7}]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• IUPAC Traditional name: natamycin
• Brand Name: Natacyn; Pimaricin

DATABASE IDS

• PubChem CID: 5281099
• CAS Number: 7681-93-8
• PubChem SID: 46509171

PROPERTIES

• Hydrophobicity(logP): 1.1
• Solubility: 4100 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
• Indication: For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.
• Pharmacology: Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.
• Affected Organisms: Various Fungus Species
• Absorption: Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.
• External Links: Wikipedia; RxList; Drugs.com