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Catalog No. DB00120 Name DrugBank
CAS Number 63-91-2 Website http://www.ualberta.ca/
M. F. C9H11NO2 Telephone (780) 492-3111
M. W. 165.18914 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 7


IUPAC name
(2S)-2-amino-3-phenylpropanoic acid
IUPAC Traditional name
(S)-alpha-Amino-beta-phenylpropionic acid


PubChem SID 46505708
PubChem CID 6140
CAS Number 63-91-2


Hydrophobicity(logP) -1.4
Solubility Slight (0.1-1%)


Description (English)
Item Information
Drug Groups approved; nutraceutical
Description An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]
Indication L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.
Pharmacology Used by the brain to produce Norepinephrine, a chemical that transmits signals between nerve cells and the brain; keeps you awake and alert; reduces hunger pains; functions as an antidepressant and helps improve memory.
Toxicity L-phenylalanine will exacerbate symptoms of phenylketonuria if used by phenylketonurics. L-phenylalanine was reported to exacerbate tardive dyskinesia when used by some with schizophrenia.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. L-phenylalanine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body, where it undergoes metabolic reactions similar to those that take place in the liver.
Absorption Absorbed from the small intestine by a sodium dependent active transport process.
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