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Rosoxacin

Catalog No. DB00817 Name DrugBank
CAS Number 40034-42-2 Website http://www.ualberta.ca/
M. F. C17H14N2O3 Telephone (780) 492-3111
M. W. 294.30466 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 696

SYNONYMS

IUPAC name
1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
IUPAC Traditional name
rosoxacin
Brand Name
Eradacil
Winuron
Roxadyl
Eracine
Eradacin
Synonyms
Acrosoxacin
Rosoxacino [INN-Spanish]
ROS
Rosoxacine [INN-French]

DATABASE IDS

CAS Number 40034-42-2
PubChem SID 46508469
PubChem CID 287180

PROPERTIES

Hydrophobicity(logP) 3
Solubility 0.0209 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.
Indication For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
Pharmacology Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Affected Organisms
Enteric bacteria and other eubacteria

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