Sodium lauryl sulfate

• Catalog No.: DB00815
• CAS Number: 151-21-3
• M. F.: C12H25NaO4S
• M. W.: 288.37927

SYNONYMS

• IUPAC name: sodium dodecyl sulfate
• IUPAC Traditional name: potassium @dodecyl sulfate
• Brand Name: Conco sulfate WA-1200; Sintapon l; Solsol needles; Sipex SD; Incronol SLS; Melanol CL 30; Avirol 118 conc; Berol 452; Duponol methyl; Maprofix wac-la; Sintrex L 100; Sipex op; Sipon LCS 98; Standapol WAQ; Stepanol WAQ; Texapon V HC; Trepenol WA; Witcolate A; Akyposal SDS; Calfoam ES 303; Dehydag sulfate GL; Dehydag sulphate GL emulsion; Dermacide; Emal 2F; Fongrapol LSS; Lanette wax s; Monogen Y 500; Richonol A; Sinnopon LS 100; Sinnopon LS 95; Stanfax 234; Stepanol WA paste; Sulfotex WA; Swascol 3L; Syntapon L; Tarapon K 12; Texapon L 100; Ultra sulfate SL-1; Alscoap LN 40A; Carsonol SLS paste b; Carsonol SLS special; Conco sulfate WAG; Cycloryl 31; Dehydag sulfate GL emulsion; Duponol QX; Duponol WA DRY; Duponol WAQ; Duponol waqe; Duponol waqm; Empicol LXV; Empicol LZ/D; Emulsogen LS; Equex S; Finasol OSR 2; Genapol LSS; Lanette wax-s; Maprofix LK; Monagen Y 100; Montopol LA paste; Perlankrol L; Pionin A 21; Polystep B 5; Rosulfan L 1; Sandet ona; Silipon RN 6031; Sinolin 90TK-N; Sipex SB; Standapol WAQ special; Stepanol WA extra; Stepanol WA special; Sulfopon WA1 Special; Supralate C; Swascol 4L; Texapon DL conc.; Texapon K 1296; Texapon K1296; Texapon V HC powder; Ufarol AM 30; WAQE; Adeka Hope LS 90; Akyposal NLS; Alscoap MP 90N; Alscoap SP 40; Alscoap-LN 90P; Anticerumen; Aquarex methyl; Avirol SL 2010; Bio-Soft SDBS 60; Calfoam SLS 30; Conco sulfate WAN; Conco sulfate WAS; Cycloryl 21; Cycloryl 21LS; Cycloryl 585N; Detergent 66; Dupanol waq; Duponal; Duponal waqe; Duponol; Duponol c; Emal 2F30; Emal o; Emal os; Emersal 6400; Empicol 0303; Empicol LPZ; Empicol LS 30; Empicol LX 2; Empicol LX 28R; Equex SP; Finasol osr(sub 2); Finasol OSR2; Gardinol; Gardinol type detergent; Jordanol SL-300; K 12 (surfactant); Maprobix neu; Maprofix 563; Maprofix wac; Monogen LH; Nissan Sintrex L 100; Nissan persoft SP; Odoripon Al 95; Orvus WA; Perklankrol ESD 60; Quolac ex-ub; Rewopol NLS 28; Rhodapon LSB; Rhodapon SB 8208S; Rhodapon SM; Richonol AF; Rolpon LS; Sipon LS 100; Sipon WD; Sipon ub; Sorpol 5029O; Sorpol 8070; Standapol 112 conc; Standapol WA-AC; Standapol WAQ-LC; Stepanal WAC; Stepanol T 28; Stepanol WA 100; Stepanol ME DRY; Stepanol ME DRY SLS; Stepanol methyl; Stepanol WA; Stepanol WAC; Sterling waq-CH; Sulfetal L 95; Sulfolyser; Sulfopon T 30; Sulfopon WA 2; Sulfopon WA3; Sulfotex wala; Sunnol LM 1130; Surfactant K12; Surfax 220; Swascol 1P; Texapon K 12; Texapon ZHC; Texapon Z high conc. needles; Adeka Hope LS 35; Alscoap LN 90; Aquarex me; Avirol 101; Carsonol SLS; Carsonol SLS-s; Caswell No. 779; Conco sulfate WN; Conco sulfate wa; Conco sulfate WA-1245; Cycloryl 580; Dehydrag sulfate GL emulsion; Dreft; Duponol QC; Duponol ME; Duponol WA; Duponol waqa; Emal 10; Emal 10 Needle; Emal 10 Powder; Emal 2F Needle; Empicol 0303VA; Empicol BSD 70; Empicol LX 28; Empicol LX 42; Empicol LXSV 938U; Empicol LY 28S; Empimin SDS; Hexamol SLS; Irium; Maprofix neu; Melanol CL; Monogen Y 100; Needle 10; Neutrazyme; Nikkol SLS; Orvus WA paste; Perlandrol L; Perlankrol E.S.D. 60; Polystep B 3; Rewopol NLS 30; Rhodapon LCP; Rhodapon SB; Rhodapon UB; Richonol C; Sipex SP; Sipex ub; Sipon LS; Sipon LSB; Sipon PD; Standapol WAS 100; Steinapol NLS; Steinapol NLS 90; Stepanol WA-100; Stepanol ME; Stepanol ME DRY AW; Stepanol methyl DRY AW; Sterling WA paste; Sterling waq-cosmetic; Sulfochem SLS; Sulfopon WA 1 Special; Sulfopon WA 3; Sulfopon WA2; Sulfopon WA 1; Texapon K 1298; Texapon K 12G; Texapon K12; Ufarol TCL 92
• Synonyms: Lauryl sulfate sodium; Lauyl sodium sulfate; Sodium monolauryl sulfate; Lauryl sulfate sodium salt; Lauryl sulfate, sodium salt; NADDS; Sodium lauryl sulphate; Sulfuric acid monododecyl ester sodium salt; SDS; Dodecyl sodium sulfate; Dodecyl alcohol, hydrogen sulfate, sodium salt; Dodecyl sulfate sodium salt; Lauryl sodium sulfate; Laurylsiran sodny [czech]; NALS; Natrium laurylsulfuricum; Natriumlaurylsulfat; Sulfuric acid dodecyl ester sodium salt; Sodium n-dodecyl sulfate; Sodiumlauryl ether sulfate; Sodium lauryl sulfate; Dodecyl sulfate sodium; Dodecyl sulfate, sodium salt; Monododecyl sodium sulfate; N-dodecyl sulfate sodium; Sodium dodecyl sulfate; Sulfuric acid, monododecyl ester, sodium salt; Sodium monododecyl sulfate

DATABASE IDS

• CAS Number: 151-21-3

PROPERTIES

• Hydrophobicity(logP): 1.60 [HANSCH,C ET AL. (1995)]
• Solubility: 100 mg/mL [SINGER,MM & TJEERDEMA,RS (1993)]

DETAILS

Description (English)

• Drug Groups: approved
• Description: Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.
• Indication: SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.
• Pharmacology: SLS is an anionic surfactant. Its amphiphilic properties make it an ideal detergent.
• Toxicity: Oral (LD50): Acute: 1288 mg/kg [Rat]
• Affected Organisms: Humans and other mammals
• References: Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300. [Pubmed] ; Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. [Pubmed] ; Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42. [Pubmed] ; Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. [Pubmed] ; Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3. [Pubmed] ; Piret J, Desormeaux A, Bergeron MG: Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets. 2002 Feb;3(1):17-30. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300. Pubmed
• Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. Pubmed
• Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42. Pubmed
• Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. Pubmed
• Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3. Pubmed
• Piret J, Desormeaux A, Bergeron MG: Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets. 2002 Feb;3(1):17-30. Pubmed