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Phenylbutazone

Catalog No. DB00812 Name DrugBank
CAS Number 50-33-9 Website http://www.ualberta.ca/
M. F. C19H20N2O2 Telephone (780) 492-3111
M. W. 308.3743 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 691

SYNONYMS

IUPAC name
4-butyl-1,2-diphenylpyrazolidine-3,5-dione
IUPAC Traditional name
phenylbutazone
Brand Name
Ecobutazone
Phenyzene
Butoz
Anuspiramin
Azolid
Arthrizon
Artizin
Busone
Butapirazol
Butapirazole
Butapyrazole
Butarecbon
Butartril
Fenylbutazon
Lingel
Reumazol
Rubatone
'Esteve'
Alqoverin
Ambene
Artrizone
Benzone
Bizolin 200
Butagesic
Butalidon
Butazina
Butazone
Bute
Butidiona
Butiwas-Simple
Cotylbutazone
Diossidone
Diphebuzol
Fenilbutine
Ia-But
Mepha-Butazon
Pyrabutol
Reumasyl
Scanbutazone
Wescozone
Alindor
Alkabutazona
Anpuzone
Apo-Phenylbutazone
Azdid
Azobutyl
B.T.Z.
Butacote
Butadion
Butaluy
Butatron
Butazolidin
Butazona
Butone
Buzon
Diozol
Elmedal
Equipalazone
Eributazone
Exrheudon N
Fenartil
Fenibutazona
Fenibutol
Fenilbutina
Fenilidina
Intalbut
Intrabutazone
Intrazone
Mephabutazone
Merizone
Nadazone
Nadozone
Neo-Zoline
Novophenyl
Phenyl-Mobuzon
Phenylbutaz
Phenylbutazonum
Phenyzone
Praecirheumin
Rectofasa
Reumune
Robizon-V
Tazone
Tetnor
Tevcodyne
Ticinil
Zolidinum
Alka Butazolidin
Anerval
Antadol
Artrizin
Artropan
Betazed
Bizolin
Bunetzone
Buta Phen
Butacompren
Butadiona
Butadione
Butalgina
Butartrina
Butazolidine
Butylpyrin
Buvetzone
Chembutazone
Digibutina
Diphenylbutazone
Equi Bute
Febuzina
Fenibutal
Fenibutasan
Fenilbutazona
Fenotone
Ipsoflame
Kadol
Malgesic
Mephabutazon
Phebuzin
Phebuzine
Phenbutazol
Phenbutazone
Phenopyrine
Pirarreumol "B"
Pirarreumol B
Pyrazolidin
Reudo
Reudox
Reumazin
Reumuzol
Reupolar
Robizone
Robizone-V
Schemergin
Shigrodin
Tencodyne
Therazone
Todalgil
Usaf Ge-15
Uzone
VAC-10
Zolaphen

DATABASE IDS

PubChem CID 4781
CAS Number 50-33-9
PubChem SID 46507038

PROPERTIES

Hydrophobicity(logP) 3.7
Solubility 47.5 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Indication For the treatment of backache and ankylosing spondylitis
Pharmacology Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Toxicity Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Affected Organisms
Humans and other mammals
External Links
Wikipedia

REFERENCES