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Polymyxin B Sulfate

Catalog No. DB00781 Name DrugBank
CAS Number 1405-20-5 Website http://www.ualberta.ca/
M. F. C56H98N16O13 Telephone (780) 492-3111
M. W. 1203.47672 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 661

SYNONYMS

IUPAC name
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
IUPAC Traditional name
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
Brand Name
Aerosporin
Poly-RX
Synonyms
Polymyxin B sulphate
Polymixin B sulfate
Polymyxin B sulfate salt

DATABASE IDS

PubChem CID 4868
PubChem SID 46507302
CAS Number 1405-20-5

PROPERTIES

Hydrophobicity(logP) -4.861
Solubility 25 mg/mL

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Indication For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Pharmacology Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant.
Toxicity Overdose can cause stomach pains, vomiting, and diarrhea.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption Not absorbed from the normal alimentary tract.
Elimination The drug is excreted slowly by the kidneys.
References
Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. [Pubmed]
Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

REFERENCES

  • Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. Pubmed
  • Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. Pubmed