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Bupranolol

Catalog No. DB08808 Name DrugBank
CAS Number 23284-25-5 Website http://www.ualberta.ca/
M. F. C14H22ClNO2 Telephone (780) 492-3111
M. W. 271.78298 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 6408

SYNONYMS

IUPAC name
tert-butyl[3-(2-chloro-5-methylphenoxy)-2-hydroxypropyl]amine
IUPAC Traditional name
bupranolol
Brand Name
Betadrenol
Ophtorenin
Adomed
Synonyms
Bupranololum
Bupranol

DATABASE IDS

CAS Number 23284-25-5

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to "propranolol":http://www.drugbank.ca/drugs/DB00571.
Indication Used to manage hypertension and tachycardia. Also used to treat glaucoma.
Pharmacology Bupranolol is a competitive, nonselective beta-blocker similar to propanolol without intrinsic sympathomimetic activity.
Toxicity Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm.
Affected Organisms
Humans and other mammals
Biotransformation Over 90% undergo first-pass metabolism. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid, of which 88% are eliminated renally within 24 hours.
Absorption Quickly and completely absorbed from the gut with less than 10% oral bioavailability.
Half Life 2-4 hours
Protein Binding 76%

REFERENCES