Tymazoline

• Catalog No.: DB08803
• CAS Number: 24243-97-8
• M. F.: C14H20N2O
• M. W.: 232.3214

SYNONYMS

• IUPAC name: 2-[5-methyl-2-(propan-2-yl)phenoxymethyl]-4,5-dihydro-1H-imidazole
• IUPAC Traditional name: tymazoline
• Brand Name: Thymazen
• Synonyms: Pernazene

DATABASE IDS

• CAS Number: 24243-97-8

DETAILS

Description (English)

• Drug Groups: approved
• Description: Tymazoline is a nasal preparation.
• Indication: For the treatment of Inflammation of the lining of the nose and paranasal sinuses and allergic inflammation of nasopharyngeal.
• Pharmacology: Tymazoline is a drug with antihistaminic and sympathomimetic properties. It locally reduces swelling, inflammation and mucosal secretions of the nasal passages.
• Toxicity: A large overdose or accidental oral intake, especially in children, may cause excessive sedation with drowsiness, reduced body temperature, heart rate relief and fluctuations in blood pressure and collapse.
• References: Levrier J, Molon-Noblot S, Duval D, Lloyd KG: A new ex vivo method for the study of nasal drops on ciliary function. Fundam Clin Pharmacol. 1989;3(5):471-82. [Pubmed] ; Lorino AM, Lofaso F, Drogou I, Abi-Nader F, Dahan E, Coste A, Lorino H: Effects of different mechanical treatments on nasal resistance assessed by rhinometry. Chest. 1998 Jul;114(1):166-70. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Levrier J, Molon-Noblot S, Duval D, Lloyd KG: A new ex vivo method for the study of nasal drops on ciliary function. Fundam Clin Pharmacol. 1989;3(5):471-82. Pubmed
• Lorino AM, Lofaso F, Drogou I, Abi-Nader F, Dahan E, Coste A, Lorino H: Effects of different mechanical treatments on nasal resistance assessed by rhinometry. Chest. 1998 Jul;114(1):166-70. Pubmed