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Hydrocortamate

Catalog No. DB00769 Name DrugBank
CAS Number 76-47-1 Website http://www.ualberta.ca/
M. F. C27H41NO6 Telephone (780) 492-3111
M. W. 475.61754 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 649

SYNONYMS

IUPAC name
2-{14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl}-2-oxoethyl 2-(diethylamino)acetate
IUPAC Traditional name
hydrocortamate
Brand Name
Magnacort
Ulcort
Hydrocortamate Hydrochloride

DATABASE IDS

CAS Number 76-47-1

PROPERTIES

Hydrophobicity(logP) 1.2

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects.
Indication Used topically as an antiinflammatory in the treatment of steroid-responsive dermatoses
Pharmacology Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.
Toxicity Side effects include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria.
Affected Organisms
Humans and other mammals
Biotransformation Primarily hepatic via CYP3A4

REFERENCES