Benzquinamide

• Catalog No.: DB00767
• CAS Number: 63-12-7
• M. F.: C22H32N2O5
• M. W.: 404.49988

SYNONYMS

• IUPAC name: 3-(diethylcarbamoyl)-9,10-dimethoxy-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-yl acetate
• IUPAC Traditional name: benzquinamide
• Brand Name: Promecon; Emeticon; BZQ; Benzchinamide; Emete-con; Quantril

DATABASE IDS

• PubChem CID: 2342
• PubChem SID: 46506155
• CAS Number: 63-12-7

PROPERTIES

• Hydrophobicity(logP): 1.7
• Solubility: 153 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: Benzquinamide is an antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
• Indication: Used to prevent and treat nausea and vomiting associated with anesthesia and surgery, administered intramuscularly or intravenously.
• Pharmacology: Benzquinamide is an antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties.
• Affected Organisms: Humans and other mammals
• Absorption: Incomplete, with 33–39% bioavailability via the capsule and suppository routes, relative to the intramuscular route.
• Half Life: 1-1.6 hours (for all formulations)