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Masoprocol

Catalog No. DB00179 Name DrugBank
CAS Number 500-38-9 Website http://www.ualberta.ca/
M. F. C18H22O4 Telephone (780) 492-3111
M. W. 302.36488 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 64

SYNONYMS

IUPAC name
4-[(2S,3R)-3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl]benzene-1,2-diol
IUPAC Traditional name
masoprocol
Brand Name
Actinex
Synonyms
NDGA
Nordihydroguaiaretic acid
meso-Nordihydroguaiaretic acid
meso-NDGA
Nordihydroguairaretic acid
Dihydronorguaiaretic acid
Masoprocolum [INN-Latin]

DATABASE IDS

PubChem SID 46508042
CAS Number 500-38-9
PubChem CID 71398

PROPERTIES

Hydrophobicity(logP) 5.8

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [PubChem]
Indication Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated).
Pharmacology Masoprocol is a novel antineoplastic agent. It is not known exactly how masoprocol works. Laboratory experiments have shown that masoprocol prevents cells similar to the ones found in actinic keratoses from multiplying. Masoprocol was withdrawn from the U.S. market in June 1996.
Toxicity Symptoms of overdose or allergic reaction include bluish coloration of skin, dizziness, severe, or feeling faint, wheezing or trouble in breathing.
Affected Organisms
Humans and other mammals
Absorption Less than 1%-2% is absorbed through the skin over a 4-day period following application.
External Links
Wikipedia

REFERENCES