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Hexachlorophene

Catalog No. DB00756 Name DrugBank
CAS Number 70-30-4 Website http://www.ualberta.ca/
M. F. C13H6Cl6O2 Telephone (780) 492-3111
M. W. 406.90354 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 636

SYNONYMS

IUPAC name
3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol
IUPAC Traditional name
hexachlorophene
Brand Name
Hexosan
Surofene
Dial
Phiso-Scrub
Acigena
Almederm
E-Z Scrub
Eleven
Exofene
G-II
HCP
Isobac
Septisol
Soy-Dome
Steral
Tersaseptic
AT-7
Bivelon
Compound G-11
Cotofilm
Dermadex
Distodin
Fascol
Fostril
Gamophen
Gamophene
Hexachlorophen
Hexazinone
Hexide
Hexophene
Nabac 25 Ec
Neosept V
Rcra Waste Number U132
Scrubteam Surgical Spongebrush
Septofen
Ster-Zac
Steraskin
Surgi-Cin
Trichlorophene
Turgex
Bilevon
Fesia-Sin
Fomac
G-Eleven
Germa-Medica
Hexa-Germ
Hexabalm
Hexachlorofen
Hexachlorophane
Hexachlorophene, Pharma
Hexafen
Hexascrub
Isobac 20
Nabac
Phisodan
Phisohex
Pre-Op
Ritosept
Septi-Soft
Surgi-Cen

DATABASE IDS

PubChem SID 46505858
PubChem CID 3598
CAS Number 70-30-4

PROPERTIES

Hydrophobicity(logP) 6.3
Solubility 140 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Indication For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Pharmacology Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Toxicity Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Protein Binding 92%
External Links
Wikipedia
RxList
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REFERENCES