Meclizine

• Catalog No.: DB00737
• CAS Number: 569-65-3
• M. F.: C25H27ClN2
• M. W.: 390.94828

SYNONYMS

• IUPAC name: 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
• IUPAC Traditional name: (+-)-meclizine
• Brand Name: Peremesin; Monamine; Navicalm; Travelon; Meclicot; Chiclida; Antivert/25; Bonine; Calmonal; Dramamine; Histamethine; Histametizine; Histametizyne; Meclizine Hcl; Meclozine; Neo-Suprimel; Vomissels; Ancolon; Antivert; Antivert/50; Bonadettes; Bonadoxin; Bonamine; Diadril; Histamethizine; Itinerol; Marex; Medivert; Neo-Istafene; Neo-Suprimal; Parachloramine; Postafene; Ravelon; Sabari; Sea-Legs; Siguran; Subari; Suprimal; Vomisseis; Ancolan; Dramamine II; Veritab

DATABASE IDS

• PubChem SID: 46507782
• PubChem CID: 4034
• CAS Number: 569-65-3

PROPERTIES

• Hydrophobicity(logP): 5.8
• Solubility: 0.1gm/100ml

DETAILS

Description (English)

• Drug Groups: approved
• Description: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]
• Indication: For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
• Pharmacology: Meclizine, a piperazine-derivative H₁-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
• Toxicity: Symptoms of overdose include drowsiness and anticholinergic effects. LD₅₀=mg/kg (orally in rat).
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• Absorption: Well absorbed
• Half Life: 6 hours
• External Links: Wikipedia; RxList; Drugs.com