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Meclizine

Catalog No. DB00737 Name DrugBank
CAS Number 569-65-3 Website http://www.ualberta.ca/
M. F. C25H27ClN2 Telephone (780) 492-3111
M. W. 390.94828 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 617

SYNONYMS

IUPAC name
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
IUPAC Traditional name
(+-)-meclizine
Brand Name
Peremesin
Monamine
Navicalm
Travelon
Meclicot
Chiclida
Antivert/25
Bonine
Calmonal
Dramamine
Histamethine
Histametizine
Histametizyne
Meclizine Hcl
Meclozine
Neo-Suprimel
Vomissels
Ancolon
Antivert
Antivert/50
Bonadettes
Bonadoxin
Bonamine
Diadril
Histamethizine
Itinerol
Marex
Medivert
Neo-Istafene
Neo-Suprimal
Parachloramine
Postafene
Ravelon
Sabari
Sea-Legs
Siguran
Subari
Suprimal
Vomisseis
Ancolan
Dramamine II
Veritab

DATABASE IDS

PubChem SID 46507782
PubChem CID 4034
CAS Number 569-65-3

PROPERTIES

Hydrophobicity(logP) 5.8
Solubility 0.1gm/100ml

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]
Indication For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Pharmacology Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Toxicity Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Well absorbed
Half Life 6 hours
External Links
Wikipedia
RxList
Drugs.com

REFERENCES