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Naftifine

Catalog No. DB00735 Name DrugBank
CAS Number 65472-88-0 Website http://www.ualberta.ca/
M. F. C21H21N Telephone (780) 492-3111
M. W. 287.39814 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 616

SYNONYMS

IUPAC name
methyl(naphthalen-1-ylmethyl)(3-phenylprop-2-en-1-yl)amine
IUPAC Traditional name
naftifine
Brand Name
Naftin
Naftifine HCl

DATABASE IDS

PubChem CID 47641
CAS Number 65472-88-0
PubChem SID 46504777

PROPERTIES

Hydrophobicity(logP) 5.4

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Indication For the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Pharmacology Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftifine has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species including Candida albicans. However it is only used to treat the organisms listed in the indications.
Affected Organisms
Yeast and other fungi
Absorption Following single topical applications of 3H-labeled naftifine gel 1% to the skin of healthy subjects, up to 4.2% of the applied dose was absorbed.
Half Life Approximately 2 to 3 days following topical administration.
Elimination Naftifine and/or its metabolites are excreted via the urine and feces with a half-life of approximately two to three days.
External Links
Wikipedia
RxList
Drugs.com

REFERENCES