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Trimipramine

Catalog No. DB00726 Name DrugBank
CAS Number 739-71-9 Website http://www.ualberta.ca/
M. F. C20H26N2 Telephone (780) 492-3111
M. W. 294.43384 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 607

SYNONYMS

IUPAC name
(3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}-2-methylpropyl)dimethylamine
IUPAC Traditional name
trimipramine
Brand Name
Surmontyl
Surmontil
Sapilent
Temaril
Synonyms
Trimipramina [INN-Spanish]
Trimipraminum [INN-Latin]
Trimeprimine
Trimeprimina [Italian]
beta-Methylimipramine

DATABASE IDS

CAS Number 739-71-9
PubChem CID 5584
PubChem SID 46507121

PROPERTIES

Hydrophobicity(logP) 4.2
Solubility Slightly soluble

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. [PubChem]
Indication For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance
Pharmacology Trimipramine is a tricyclic antidepressant. It was thought that tricyclic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: a1 and b1 receptors are sensitized, a2 receptors are desensitised (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain. A precise mechanism for their analgesic action is unknown, but it is thought that they modulate anti-pain opioid systems in the CNS via an indirect serotonergic route. They are also effective in migraine prophylaxis, but not in abortion of acute migraine attack. The mechanism of their anti-migraine action is also thought to be serotonergic.
Toxicity Side effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Rapid absorption
Half Life 11-18 hrs
Protein Binding 93%-96% (to plasma proteins)
External Links
Wikipedia
RxList
PDRhealth
Drugs.com

REFERENCES