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Pyruvic acid

Catalog No. DB00119 Name DrugBank
CAS Number 127-17-3 Website http://www.ualberta.ca/
M. F. C3H4O3 Telephone (780) 492-3111
M. W. 88.06206 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 6

SYNONYMS

IUPAC name
2-oxopropanoic acid
IUPAC Traditional name
pyruvic acid
Synonyms
2-Oxopropanoate
2-Oxopropanoic acid
2-Oxopropionic acid
a-Ketopropionic acid
Acetylformic acid
BTS
Pyroracemic acid
Pyruvate

DATABASE IDS

CAS Number 127-17-3
PubChem CID 1060
PubChem SID 46505692

PROPERTIES

Hydrophobicity(logP) -0.5
Solubility 1000 mg/mL at 20 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

DETAILS

Description (English)
Item Information
Drug Groups approved; nutraceutical
Description An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Indication For nutritional supplementation, also for treating dietary shortage or imbalance
Pharmacology Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production. Pyruvate is widely found in living organisms. It is not an essential nutrient since it can be synthesized in the cells of the body. Certain fruits and vegetables are rich in pyruvate. For example, an average-size red apple contains approximately 450 milligrams. Dark beer and red wine are also rich sources of pyruvate. Recent research suggests that pyruvate in high concentrations may have a role in cardiovascular therapy, as an inotropic agent. Supplements of this dietary substance may also have bariatric and ergogenic applications.
Toxicity Those taking large doses of supplemental pyruvate—usually greater than 5 grams daily—have reported gastrointestinal symptoms, including abdominal discomfort and bloating, gas and diarrhea. One child receiving pyruvate intravenously for restrictive cardiomyopathy died.
Affected Organisms
Humans and other mammals
Biotransformation In the liver, pyruvate is metabolized via several pathways.
Absorption Pyruvate is absorbed from the gastrointestinal tract from whence it is transported to the liver via the portal circulation.
External Links
Wikipedia
PDRhealth

REFERENCES