Norethindrone

• Catalog No.: DB00717
• CAS Number: 68-22-4
• M. F.: C20H26O2
• M. W.: 298.41924

SYNONYMS

• IUPAC name: (1S,2R,10R,11S,14R,15S)-14-ethynyl-14-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
• IUPAC Traditional name: norethindrone
• Brand Name: Norfor; Nor-Q.D.; ENT; Ethynylnortestosterone; Triella; Norethisterone; Anhydrohydroxynorprogesterone; Brevinor 28; Brevinor-1 28; Ethynylmortestosterone; Milli; Nelova; Norethadrone; Norethindrone Acetate; Norgestin; Ovysmen 1 35; Primolut N; Tri-Norinyl; Anovule; Conludag; Gencept; Microneth; Micronovum; Necon; Norethin; Norethyndron; Noriday 28; Norimin; Norlestrin; Norpregneninlone; Ortho 1 35; Ortho-Novum 1 35; Ovcon; Ovysmen; Palonyl; Synphase; Synphasic 28; Trinovum; Trinovum 21; Utovlan; Utovlar; Anovulatorio; Aygestin; Brevicon; Brevinor; Brevinor-1 21; Camila; Ciclovulan; Conceplan; Conludaf; Demulen; Errin; Estrinor; Ethinylnortestosterone; Genora; Jenest; Jenest-28; Menzol; Micronett; Minovlar; N.E.E.; NET; Neocon; Nor-Qd; Norcept; Norcolut; Norethin 1/50 M; Norethindrone Norethisterone; Norethisteron; Norethisterone [Progestins]; Norethynodron; Noretisterone [Dcit]; Noriday; Norlutate; Norluten; Norlutin; Norluton; Normapause; Orlest; Ortho 7 7 7; Ortho-Novum; Ortho-Novum 1 50; Ortho-Novum 7 7 7; Ovysmen 0.5 35; Perovex; Primolut-N; Proluteasi; Loestrin 24 Fe; Binovum; Brevinor 21; Gestest; Loestrin; Micronor; Mini-Pe; Mini-Pill; Modicon; Nodiol; Noraethisteronum; Noralutin; Norcept-E; Noresthisterone; Norethin 1/35 E; Norethisteronum [INN-Latin]; Norethynodrone; Noretisterona [INN-Spanish]; Norinyl; Norpregneninolone; Norpregneninotone

DATABASE IDS

• PubChem SID: 46504816
• CAS Number: 68-22-4
• PubChem CID: 6230

PROPERTIES

• Hydrophobicity(logP): 3.2
• Solubility: 7.04 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception. [PubChem]
• Indication: For use as an oral contraceptive in the prevention of pregnancy.
• Pharmacology: Norethindrone is a synthetic oral progestin. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. As an oral contraceptive, norethindrone is available as either a single agent or in combination with an estrogen.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• Absorption: Absolute oral bioavailability approximately 64%
• Half Life: 7 hours
• Protein Binding: >95%
• External Links: Wikipedia; RxList; PDRhealth; Drugs.com