Nicergoline

• Catalog No.: DB00699
• CAS Number: 27848-84-6
• M. F.: C24H26BrN3O3
• M. W.: 484.38554

SYNONYMS

• IUPAC name: [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
• IUPAC Traditional name: nicergoline
• Brand Name: Nargoline; Nicergolin [German]; Nicotergoline; Sermion; MNE; Nicergolina [Dcit]; Nicergoline [Usan:Ban:Inn:Jan]; Nicergolinum [INN-Latin]; Nimergoline; Nimergoline Base; Vasospan

DATABASE IDS

• CAS Number: 27848-84-6
• PubChem SID: 46508741
• PubChem CID: 34040

PROPERTIES

• Hydrophobicity(logP): 3.3

DETAILS

Description (English)

• Drug Groups: approved
• Description: An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]
• Indication: For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
• Pharmacology: Nicergoline is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
• Affected Organisms: Humans and other mammals
• References: Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52. Pubmed