Fluorescein

• Catalog No.: DB00693
• CAS Number: 2321-07-5
• M. F.: C20H12O5
• M. W.: 332.30628

SYNONYMS

• IUPAC name: 3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthene]-3-one
• IUPAC Traditional name: fluorescein
• Brand Name: Acid Yellow 73; Fluorescite; Fluorescein disodium salt dihydrate; Uranine; Eosin; Fluorescein Sodium salt; Fluorescein acid; Fluorescein disodium salt; Fluorescein sodium; Fluorescein, Disodium Salt, Fluorescein, disodium salt; Funduscein-25; Uranin

DATABASE IDS

• PubChem CID: 16850
• CAS Number: 2321-07-5
• PubChem SID: 46504703

PROPERTIES

• Hydrophobicity(logP): 3.4
• Solubility: 600 mg/mL (sodium salt)

DETAILS

Description (English)

• Drug Groups: approved
• Description: A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
• Indication: For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
• Affected Organisms: Humans and other mammals
• Absorption: Rapidly distributed
• Protein Binding: 85%
• Elimination: Fluorescein and its metabolites are mainly eliminated via renal excretion.
• Distribution: * 0.5 L/kg
• Clearance: * renal cl=1.75 mL/min/kg [After IV administration]; * hepatic cl=1.50 mL/min/kg [After IV administration]
• References: Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31. [Pubmed]
• External Links: Wikipedia; RxList

REFERENCES

• Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31. Pubmed