Cephaloglycin

• Catalog No.: DB00689
• CAS Number: 3577-01-3
• M. F.: C18H19N3O6S
• M. W.: 405.42496

SYNONYMS

• IUPAC name: (6R,7R)-3-[(acetyloxy)methyl]-7-[(2R)-2-amino-2-phenylacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• IUPAC Traditional name: cephaloglycin
• Brand Name: D-Cephaloglycine; CEG; Cefaloglicina [INN-Spanish]; Cefaloglycin; Cefaloglycine [INN-French]; Cefaloglycinum [INN-Latin]; Cephaloglycin anhydrous; Cephaloglycine; Cephaoglycin acid; Kafocin; Kefglycin

DATABASE IDS

• PubChem SID: 46506850
• CAS Number: 3577-01-3
• PubChem CID: 19150

PROPERTIES

• Hydrophobicity(logP): -0.3
• Solubility: 154 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A cephalorsporin antibiotic. [PubChem]
• Indication: For treatment of severe infections caused by susceptible bacteria.
• Pharmacology: Cephaloglycin is an antibiotic related to cephalosporin but no longer in common use. It is an orally absorbed derivative of cephalosporin C.
• Toxicity: Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
• Affected Organisms: Enteric bacteria and other eubacteria
• Absorption: Well absorbed following oral administration.
• References: Tune BM, Hsu CY: The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem. J Am Soc Nephrol. 1990 Nov;1(5):815-21. [Pubmed] ; Tune BM, Fravert D, Hsu CY: Oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin. Biochem Pharmacol. 1989 Mar 1;38(5):795-802. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Tune BM, Hsu CY: The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem. J Am Soc Nephrol. 1990 Nov;1(5):815-21. Pubmed
• Tune BM, Fravert D, Hsu CY: Oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin. Biochem Pharmacol. 1989 Mar 1;38(5):795-802. Pubmed