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Fludrocortisone

Catalog No. DB00687 Name DrugBank
CAS Number 127-31-1 Website http://www.ualberta.ca/
M. F. C21H29FO5 Telephone (780) 492-3111
M. W. 380.4503632 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 569

SYNONYMS

IUPAC name
(1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
IUPAC Traditional name
fludrocortisone
Brand Name
F-COL
9.Alpha.-Fluorohydrocortisone
Fludrocortisona [INN-Spanish]
Fludrocortisone Acetate
9 alpha-Fluorocortisol
9 .Alpha. Ff
9 Alpha Ff
Astonin-H
Florinef
Fludrocortisonum [INN-Latin]
Fludrocortone
Fludronef
Fluodrocortisone
Fluohydrocortisone
Fluorocortisol
ZK5
9 alpha-Fludrocortisone
9.Alpha.-Fluorocortisol
Alflorone
F-Cortef
Fludrone
Fluohydrisone
Fluorocortisone

DATABASE IDS

PubChem CID 31378
CAS Number 127-31-1
PubChem SID 46508616

PROPERTIES

Hydrophobicity(logP) 0.3
Solubility 140 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A synthetic mineralocorticoid with anti-inflammatory activity. [PubChem]
Indication For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
Pharmacology Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
Toxicity Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic, some renal.
Half Life 3.5 hours
Protein Binding High
External Links
Wikipedia
RxList
Drugs.com

REFERENCES