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Thioridazine

Catalog No. DB00679 Name DrugBank
CAS Number 50-52-2 Website http://www.ualberta.ca/
M. F. C21H26N2S2 Telephone (780) 492-3111
M. W. 370.57454 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 561

SYNONYMS

IUPAC name
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
IUPAC Traditional name
thioridazine
Brand Name
Mellaril-S
Thioridazine, Prolongatum
Sonapax
Metlaril
Aldazine
Mallorol
Mellaril
Mellerets
Mellerette
Melleril
Novoridazine
Ridazin
Ridazine
Thioridazine Hcl Intensol
Malloryl
Meleril
Mellaril Hydrochloride
Mellarit
Melleretten
Orsanil
Sonapax Hydrochloride
Stalleril
Tioridazin
Synonyms
Thioridazine Hcl
Thioridazine Chloride
Thioridazine Hydrochloride
Thioridazin
Thoridazine Hydrochloride

DATABASE IDS

CAS Number 50-52-2
PubChem SID 46509070
PubChem CID 5452

PROPERTIES

Hydrophobicity(logP) 5.9
Solubility 0.0336 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618)
Indication For the treatment of schizophrenia and generalized anxiety disorder.
Pharmacology Thioridazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Thioridazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Toxicity LD50=956-1034 mg/kg (Orally in rats); Agitation, blurred vision, coma, confusion, constipation, difficulty breathing, dilated or constricted pupils, diminished flow of urine, dry mouth, dry skin, excessively high or low body temperature, extremely low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, shock
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption 60%
Half Life 21-25 hours
Protein Binding 95%
External Links
Wikipedia
RxList
Drugs.com

REFERENCES