Flumethasone Pivalate

• Catalog No.: DB00663
• CAS Number: 2002-29-1
• M. F.: C27H36F2O6
• M. W.: 494.5679464

SYNONYMS

• IUPAC name: 2-[(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl 2,2-dimethylpropanoate
• IUPAC Traditional name: flumethasone pivalate
• Brand Name: Locorten

DATABASE IDS

• CAS Number: 2002-29-1
• PubChem CID: 443980
• PubChem SID: 46505121

PROPERTIES

• Hydrophobicity(logP): 2.1
• Solubility: 0.392 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
• Indication: For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions
• Pharmacology: Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
• Toxicity: Can lead to signs of irritation such as burning sensation, itching or skin rash at the site of application; hypersensitivity reactions.
• Affected Organisms: Humans and other mammals
• Biotransformation: Primarily hepatic
• Absorption: Minimal if applied topically