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Gonadorelin

Catalog No. DB00644 Name DrugBank
CAS Number 6918-09-8 Website http://www.ualberta.ca/
M. F. C55H75N17O13 Telephone (780) 492-3111
M. W. 1182.2901 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 526

SYNONYMS

IUPAC name
N-(1-{2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl}-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl)-2-{2-[2-(3-hydroxy-2-{2-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamide
IUPAC Traditional name
gonadorelin
Brand Name
Mammalian GnRH
Porcine LH-releasing factor
Synthetic Gn-RH
Lutrefact
Fertagyl
Lutrepulse
Dirigestran Spofa
Gonadorelina [INN-Spanish]
Human LH-RH
Hypocrine
Lutrepulse KIT
Relisorm
Synthetic LH-RF
Synthetic LRF
Synthetic gonadoliberin
Dirigestran
Factrel
Gonadorelinum [INN-Latin]
Gonadotropin releasing hormone
Gonadotropin-releasing factor
Gonadotropin-releasing hormone
Luforan
Lutal
Lutamin
Mammalian LH-RH
Ovine LH-RH
Porchine LH-RH
Relefact
Relisorm L
Synthetic LH-FSH releasing hormone
Synthetic LH-RH
Synthetic LH-releasing factor
Synthetic LH-releasing hormone
Synthetic decapeptide FSH/LH-RH

DATABASE IDS

PubChem SID 46506144
CAS Number 6918-09-8
PubChem CID 36523

PROPERTIES

Hydrophobicity(logP) -3.6
Solubility 1 mg/mL

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
Indication For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Pharmacology Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Toxicity LD50>3000 mg/kg (rat, oral)
Affected Organisms
Humans and other mammals
Biotransformation Rapidly hydrolyzed to inactive peptide components
Absorption Rapidly absorbed when injected
Half Life Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes
References
Dungan HM, Clifton DK, Steiner RA: Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2006 Mar;147(3):1154-8. Epub 2005 Dec 22. [Pubmed]
Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A: Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett. 2006 Jul 3;401(3):225-30. Epub 2006 Apr 18. [Pubmed]
External Links
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REFERENCES

  • Dungan HM, Clifton DK, Steiner RA: Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2006 Mar;147(3):1154-8. Epub 2005 Dec 22. Pubmed
  • Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A: Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett. 2006 Jul 3;401(3):225-30. Epub 2006 Apr 18. Pubmed