Butoconazole

• Catalog No.: DB00639
• CAS Number: 64872-77-1
• M. F.: C19H17Cl3N2S
• M. W.: 411.77568

SYNONYMS

• IUPAC name: 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-imidazole
• IUPAC Traditional name: butoconazole
• Brand Name: Gynazole-1; Femstat 3; Femstat
• Synonyms: Butoconazol [INN-Spanish]; Butoconazole nitrate; Butoconazolum [INN-Latin]

DATABASE IDS

• CAS Number: 64872-77-1
• PubChem SID: 46508016
• PubChem CID: 47472

PROPERTIES

• Hydrophobicity(logP): 6.7
• Solubility: Nitrate salt: 0.26 mg/ml (practically insoluble)

DETAILS

Description (English)

• Drug Groups: approved
• Description: Butoconazole is an imidazole antifungal used in gynecology.
• Indication: For the local treatment of vulvovaginal candidiasis (infections caused by Candida)
• Pharmacology: Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis.
• Toxicity: Oral, rat: LD₅₀ = >1720 mg/kg.
• Affected Organisms: Fungi, yeast and protozoans
• Absorption: Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average.
• External Links: Wikipedia; RxList; PDRhealth; Drugs.com