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Dexmedetomidine

Catalog No. DB00633 Name DrugBank
CAS Number 113775-47-6 Website http://www.ualberta.ca/
M. F. C13H16N2 Telephone (780) 492-3111
M. W. 200.27954 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 515

SYNONYMS

IUPAC name
5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
IUPAC Traditional name
dexmedetomidine
Brand Name
PRECEDEX
Synonyms
Medetomidina [Spanish]
Medetomidinum [Latin]
Medetomidine

DATABASE IDS

CAS Number 113775-47-6

PROPERTIES

Hydrophobicity(logP) 2.8
Solubility Freely soluble in water

DETAILS

Description (English)
Item Information
Drug Groups approved
Description An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. [PubChem]
Indication For sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting, also used in pain relief; anxiety reduction and analgesia
Pharmacology Dexmedetomidine activates 2-adrenoceptors, and causes the decrease of sympathetic tone, with attenuation of the neuroendocrine and hemodynamic responses to anesthesia and surgery; it reduces anesthetic and opioid requirements; and causes sedation and analgesia.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Half Life 2 hours
Protein Binding 94%
Elimination A mass balance study demonstrated that after nine days an average of 95% of the radioactivity, following intravenous administration of radiolabeled dexmedetomidine, was recovered in the urine and 4% in the feces. Fractionation of the radioactivity excreted in urine demonstrated that products of N-glucuronidation accounted for approximately 34% of the cumulative urinary excretion. The majority of metabolites are excreted in the urine.
Distribution * 118 L
Clearance * 39 L/h [Healthy volunteers receiving IV infusion (0.2-0.7 mcg/kg/hr)]
External Links
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REFERENCES