Triamcinolone

• Catalog No.: DB00620
• CAS Number: 124-94-7
• M. F.: C21H27FO6
• M. W.: 394.4338832

SYNONYMS

• IUPAC name: (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
• IUPAC Traditional name: triamcinolone
• Brand Name: Sk-Triamcinolone; Triamcet; Adcortyl; Trilone; Kenacort-A; Polcortolon; Delphicort; Kenacort; Kenacort-Ag; Kenalog; Ledercort; Nasacort Hfa; Oracort; Tri-Nasal; Triacort; Triamcinolon; Triatex; Fougera; Aristocort Tablets; Aristogel; Aristospan; Celeste; Cinolone-T; Kenalog in Orabase; Kenalog-10; Nasacort; Omcilon; Omicilon; Oralone; Orion; Rodinolone; Triam-Tablinen; Triamcinlon; Vetalog; Tristoject; Aristocort; Aristocort A; Azmacort; Cinolone; Flutex; Kenalog-40; Kenalog-H; Nasacort Aq; Triacet; Tricortale; Triderm; Trymex; Volon; Volon A
• Synonyms: Triamcinolone acetonide; Fluoxyprednisolone; Tiamcinolonum [INN-Latin]; Triamcinalone; Triamcinolona [INN-Spanish]; Triamcinolonum [INN]; Triamcinolone diacetate; Triamcinolone hexacetonide; Fluoxiprednisolone

DATABASE IDS

• CAS Number: 124-94-7
• PubChem CID: 31307
• PubChem SID: 46507950

PROPERTIES

• Hydrophobicity(logP): 0.2
• Solubility: 80 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
• Indication: For the treatment of perennial and seasonal allergic rhinitis.
• Pharmacology: Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.
• Toxicity: LD₅₀=>500mg/kg (in rats)
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Absorption: Rapid absorption following oral administration
• Half Life: 88 minutes
• Protein Binding: 68%
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