Home > Compound List > Product Information
Pyridoxine_Molecular_structure_CAS_65-23-6)
Click picture or here to close

Pyridoxine

Catalog No. DB00165 Name DrugBank
CAS Number 65-23-6 Website http://www.ualberta.ca/
M. F. C8H11NO3 Telephone (780) 492-3111
M. W. 169.17784 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 50

SYNONYMS

IUPAC name
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
IUPAC Traditional name
pyridoxine
Brand Name
Gravidox
Pyridox
Hexa-Betalin
Alestrol
Bonasanit
Hexermin
Hexermine
Pydox
Pyridipca
Pyridoxine-HCl Microencapsulated
Rodex TD
Tex Six T.R.
Aderoxine
Becilan
Beesix
Benadon
Campoviton 6
Hexavibex
Hexobion
Hydoxin
Nestrex
Vitamin B6
Vitaped
Synonyms
Hexabione hydrochloride
Adermine hydrochloride
PN
Vitamin B6
Aderomine hydrochloride
Pyridoxine Chloride
Adermin hydrochloride
Pyridoxine HCl
Pyridoxin hydrochloride
Pyridoxine hydrochloride
Pyridoxine hydrogen chloride
Pyridoxinium Chloride
Pyridoxinum Hydrochloricum
Pyridoxol hydrochloride

DATABASE IDS

PubChem SID 46508560
PubChem CID 1054
CAS Number 65-23-6

PROPERTIES

Hydrophobicity(logP) -0.77 [SANGSTER (1993)]
Solubility 2.2E+005 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved; nutraceutical
Description Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
Indication For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Pharmacology Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Toxicity Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
Half Life 15-20 days
Protein Binding 22%
External Links
Wikipedia
PDRhealth
Drugs.com

REFERENCES