Candoxatril

• Catalog No.: DB00616
• CAS Number: 118785-03-8
• M. F.: C29H41NO7
• M. W.: 515.63834

SYNONYMS

• IUPAC name: 4-{1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentaneamido}cyclohexane-1-carboxylic acid
• IUPAC Traditional name: 4-{1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentaneamido}cyclohexane-1-carboxylic acid
• Brand Name: Candoxatrilat

DATABASE IDS

• CAS Number: 118785-03-8

PROPERTIES

• Hydrophobicity(logP): 3.7

DETAILS

Description (English)

• Drug Groups: approved
• Description: Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure.
• Indication: For treatment of hypertension, improve exercise capacity in patients with CHF receiving angiotensin converting enzyme inhibition.
• Pharmacology: Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure in man.
• Affected Organisms: Humans and other mammals