Oxytetracycline

• Catalog No.: DB00595
• CAS Number: 79-57-2
• M. F.: C22H24N2O9
• M. W.: 460.43396

SYNONYMS

• IUPAC name: (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• IUPAC Traditional name: oxytetracycline
• Brand Name: Oxytetracycline HCl; Terramycin; Oxytetracycline anhydrous

DATABASE IDS

• PubChem SID: 46507025
• PubChem CID: 5280972
• CAS Number: 79-57-2

PROPERTIES

• Hydrophobicity(logP): -1.3
• Solubility: 0.6 mg/mL (6.9 mg/mL as HCl salt)

DETAILS

Description (English)

• Drug Groups: approved
• Description: A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. [PubChem]
• Indication: Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
• Pharmacology: Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the tetracyclines to be discovered. Oxytetracycline, like other tetracyclines, is used to treat many infections common and rare. Its better absorption profile makes it preferable to tetracycline for moderately severe acne, but alternatives sould be sought if no improvement occurs by 3 months.
• Toxicity: Adverse effects may include stomach or bowel upsets and rarely allergic reactions. Very rarely severe headache and vision problems may be signs of dangerous intracranial hypertenion.
• Affected Organisms: Enteric bacteria and other eubacteria
• Absorption: Readily absorbed following oral administration.
• External Links: Wikipedia; RxList