Fluticasone Propionate

• Catalog No.: DB00588
• CAS Number: 80474-14-2
• M. F.: C25H31F3O5S
• M. W.: 500.5708496

SYNONYMS

• IUPAC name: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl propanoate
• IUPAC Traditional name: fluticasone propionate
• Brand Name: Flovent; Flunase; Flovent Diskus 100; Advair Diskus 250/50; Advair Diskus 100/50; Advair Diskus 500/50; Cutivate; Flixonase; Flixotide; Flonase; Flovent Diskus 250; Flovent Diskus 50; Flovent HFA; Advair Diskus
• Synonyms: fluticasone propionate

DATABASE IDS

• PubChem SID: 46506140
• CAS Number: 80474-14-2
• PubChem CID: 444036

PROPERTIES

• Hydrophobicity(logP): 3.4
• Solubility: 0.51 mg/L (insoluble)

DETAILS

Description (English)

• Drug Groups: approved; investigational
• Description: Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.
• Indication: For the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
• Pharmacology: Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.
• Affected Organisms: Humans and other mammals
• Biotransformation: Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5-fluoromethyl carbothioate grouping. This transformation occurs in 1 metabolic step to produce the inactive 17-(beta)-carboxylic acid metabolite, the only known metabolite detected in man.
• Absorption: The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier.
• Half Life: 10 hours
• Protein Binding: 91%
• Distribution: * 2.3 to 16.7 L/kg
• Clearance: * 1093 mL/min
• External Links: RxList; Drugs.com