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Mazindol

Catalog No. DB00579 Name DrugBank
CAS Number 22232-71-9 Website http://www.ualberta.ca/
M. F. C16H13ClN2O Telephone (780) 492-3111
M. W. 284.74022 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 461

SYNONYMS

IUPAC name
5-(4-chlorophenyl)-2H,3H,5H-imidazo[2,1-a]isoindol-5-ol
IUPAC Traditional name
mazindol
Brand Name
Magrilon
Mazildene
Terenac
Mazindol [USAN:BAN:INN]
Sanorex
DEA No. 1605
Dimagrir
Mazanor
Mazindolum [INN-Latin]
Teronac

DATABASE IDS

PubChem SID 46509094
CAS Number 22232-71-9
PubChem CID 4020

PROPERTIES

Hydrophobicity(logP) 3.7

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Tricyclic anorexigenic agent unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. [PubChem]
Indication Used in short-term (a few weeks) treatment of exogenous obesity in conjunction with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in patients with a body mass index of 30 kg of body weight per height in meters squared (kg/m2) or in patients with a body mass index of 27 kg/m2 in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia.
Pharmacology Mazindol is a sympathomimetic amine, which is similar to an amphetamine. Mazindol stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite. Sympathomimetic appetite suppressants are used in the short-term treatment of obesity. Their appetite-reducing effect tends to decrease after a few weeks. Because of this, these medicines are useful only during the first few weeks of a weight-loss program.
Toxicity Symptoms of a mazindol overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Half Life 10-13 hours
External Links
Wikipedia
Drugs.com

REFERENCES