Home > Compound List > Product Information
Nonoxynol-9_Molecular_structure_CAS_26571-11-9)
Click picture or here to close

Nonoxynol-9

Catalog No. DB06804 Name DrugBank
CAS Number 26571-11-9 Website http://www.ualberta.ca/
M. F. C33H60O10 Telephone (780) 492-3111
M. W. 616.8235 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 4481

SYNONYMS

IUPAC name
1-(4-nonylphenyl)-1,4,7,10,13,16,19,22,25-nonaoxaheptacosan-27-ol
IUPAC Traditional name
nonoxynol 9
Brand Name
Gynoll
Conceptrol
Today
VCF
Advantage 24
Delfen
Semicid
Synonyms
N-9

DATABASE IDS

CAS Number 26571-11-9
PubChem SID 99443296
PubChem CID 72385

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups approved; withdrawn
Description Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants. It is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market.
Indication Nonoxynol 9 is a surfactant spermicide used for contraception in spermicidal creams, jellies, foams, gel, and lubricants. It is also used in conjuction with other methods of contraception, including condoms, cervical caps and diaphragms.
Toxicity The major drawback of nonoxynol-9 is its detergent-type action on epithelial cells and the normal vaginal flora. Detergent-type spermicides alter the vaginal flora, possibly leading to an increased risk of opportunistic infections. These are known to enhance the susceptibility of the epithelium of the lower genital tract to HIV and human papillomavirus infection. N-9 can cause vaginal irritation and allergic vaginitis as well as genital irritation in male partners.
References
Iyer V, Poddar SS: Update on nonoxynol-9 as vaginal spermicide. Eur J Contracept Reprod Health Care. 2008 Dec;13(4):339-50. [Pubmed]
External Links
Wikipedia

REFERENCES

  • Iyer V, Poddar SS: Update on nonoxynol-9 as vaginal spermicide. Eur J Contracept Reprod Health Care. 2008 Dec;13(4):339-50. Pubmed