beta-Naphthoflavone

• Catalog No.: DB06732
• CAS Number: 6051-87-2
• M. F.: C19H12O2
• M. W.: 272.29738

SYNONYMS

• IUPAC name: 3-phenyl-1H-benzo[f]chromen-1-one
• IUPAC Traditional name: β-naphthoflavone
• Synonyms: BNF; WLN: T B666 CV FOJ ER; {1H-Naphtho[2,} 1-b\]pyran-1-one, 3-phenyl-; 3-phenyl-1H-benzo[f]chromen-1-one (ACD/Name 4.0); 3-Phenyl-1H-benzo[f]chromen-1-one; 5,6-benzoflavone; beta-NF; 1H-Naphtho(2,1-b)pyran-1-one, 3-phenyl-; 1H-Naphtho[2,1-b]pyran-1-one, 3-phenyl-; 3-Phenyl-1H-naphtho[2,1-b]pyran-1-one; 3-Phenyl-benzo[f]chromen-1-one; 5,6 Benzoflavone; BIDD:ER0570; N3633_SIGMA; {3-Phenyl-1H-naphtho[2,} 1-b\]pyran-1-one; 3-Phenyl-1H-naphtho(2,1-b)pyran-1-one

DATABASE IDS

• PubChem CID: 2361
• CAS Number: 6051-87-2
• PubChem SID: 99443278

DETAILS

Description (English)

• Drug Groups: experimental
• Description: beta-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). β-Naphthoflavone is a putative chemopreventive agent.
• References: Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L: Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture. Planta Med. 2007 Jul;73(8):742-7. Epub 2007 Jun 28. [Pubmed] ; Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S: Modulation of multigene expression and proteome profiles by chemopreventive agents. Mutat Res. 2005 Dec 11;591(1-2):212-23. Epub 2005 Aug 3. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L: Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture. Planta Med. 2007 Jul;73(8):742-7. Epub 2007 Jun 28. Pubmed
• Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S: Modulation of multigene expression and proteome profiles by chemopreventive agents. Mutat Res. 2005 Dec 11;591(1-2):212-23. Epub 2005 Aug 3. Pubmed