| Item |
Information |
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Drug Groups
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approved |
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Description
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Fesoterodine is an antimuscarinic prodrug used for treating overactive bladder syndrome. |
| Indication |
For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence). |
| Pharmacology |
Fesoterodine is a prodrug. In vivo it is broken down into its active metabolite, 5-hydroxymethyl tolterodine, by plasma esterases. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Therefore, acting as a competitive muscarinic receptor antagonist, fesoterodine ultimately acts to decrease the detrusor pressure by its muscarinic antagonism, thereby decreasing bladder contraction and consequently, the urge to urinate. |
| Affected Organisms |
| • |
Humans and other mammals |
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| Half Life |
7-8 hours for the active metabolite. |
| External Links |
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