Ibudilast

• Catalog No.: DB05266
• CAS Number: 50847-11-5
• M. F.: C14H18N2O
• M. W.: 230.30552

SYNONYMS

• IUPAC name: 2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one
• IUPAC Traditional name: ketas
• Synonyms: Ibudilastum; Eyevinal; 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine; Lopac-I-0157; Ke tas; MN-166; AV-411; 2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine; 3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine; I0157_SIGMA; Ibudilast (jan/inn); Ibudilast [inn:jan]; Ketas; Ketas (TN); Tocris-1694; UNII-M0TTH61XC5; Ibudilastum [latin]; Pyrazolo(1,5-a)pyridine, 3-isobutyryl-2-isopropyl-

DATABASE IDS

• CAS Number: 50847-11-5
• PubChem CID: 3671
• PubChem SID: 99443231

DETAILS

Description (English)

• Drug Groups: approved; investigational
• Description: Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S. (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan.
• Indication: For the treatment of multiple sclerosis, asthma, and cerebrovascular disease.
• Toxicity: Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
• Affected Organisms: Humans and other mammals
• Half Life: 19 hours
• External Links: Wikipedia