| Item |
Information |
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Drug Groups
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approved |
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Description
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Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. [Wikipedia] |
| Indication |
Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. |
| Pharmacology |
Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated. |
| Toxicity |
Acute oral toxicity (LD50) in rat is 10001 mg/kg.
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| Affected Organisms |
| • |
Yeast and other fungi |
| • |
Various gram-negative and gram-positive eubacteria |
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| Absorption |
Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue. |
| References |
| • |
Fox CL Jr, Modak SM: Mechanism of silver sulfadiazine action on burn wound infections. Antimicrob Agents Chemother. 1974 Jun;5(6):582-8.
[Pubmed]
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| • |
Russell AD, Hugo WB: Antimicrobial activity and action of silver. Prog Med Chem. 1994;31:351-70.
[Pubmed]
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| • |
Percival SL, Bowler PG, Russell D: Bacterial resistance to silver in wound care. J Hosp Infect. 2005 May;60(1):1-7.
[Pubmed]
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| External Links |
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