Permethrin

• Catalog No.: DB04930
• CAS Number: 52645-53-1
• M. F.: C21H20Cl2O3
• M. W.: 391.2877

SYNONYMS

• IUPAC name: (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
• IUPAC Traditional name: permethrin
• Brand Name: Elimite; Nix Cream Rinse; Elimite Cream; PerFoam; Acticin Cream; Nix
• Synonyms: permethrin

DATABASE IDS

• PubChem SID: 46505374
• CAS Number: 52645-53-1
• PubChem CID: 40326

PROPERTIES

• Hydrophobicity(logP): 6.50 [HANSCH,C ET AL. (1995)]
• Solubility: 6e-06 mg/mL at 20 oC [USDA PESTICIDE PROP DATABASE]

DETAILS

Description (English)

• Drug Groups: approved; investigational
• Description: A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
• Indication: For the treatment of infestation with Sarcoptes scabiei (scabies).
• Pharmacology: Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
• Toxicity: Oral, rat LD₅₀: 430 - 4000 mg/kg; skin, rabbit LD₅₀: 2000 mg/kg.
• Affected Organisms: Scabies (Sarcoptes scabei) and other insects
• Biotransformation: Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
• Absorption: Poorly absorbed through the skin.
• Elimination: Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
• References: Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. Pubmed