Home > Compound List > Product Information
Flunarizine_Molecular_structure_CAS_52468-60-7)
Click picture or here to close

Flunarizine

Catalog No. DB04841 Name DrugBank
CAS Number 52468-60-7 Website http://www.ualberta.ca/
M. F. C26H26F2N2 Telephone (780) 492-3111
M. W. 404.4948464 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 4385

SYNONYMS

IUPAC name
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
IUPAC Traditional name
flunarizine
Brand Name
Apo-flunarizine capsules
Issium
Flufenal
Sibelium
Novo-Flunarizine
Vertix
Zinasen
Fluvert
Synonyms
(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine
Flunarizinum [inn-latin]
Flunarizina [inn-spanish]
1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine
Flunarizine Hydrochloride
flunarizine dihydrochloride

DATABASE IDS

CAS Number 52468-60-7
PubChem CID 941361
PubChem SID 46507129

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Indication Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Pharmacology Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic, to two metabolites via N-dealylation and hydroxylation.
Absorption 85% following oral administration.
Half Life 18 days
Protein Binding 99% bound to plasma proteins
External Links
Wikipedia

REFERENCES